Lupine Publishers | Trends in Ophthalmology Open Access Journal
Abstract
Purpose: To report Yag laser clot blast therapy
for central retinal venous occlusion.
Methods & Materials: Prospective study of
10 patients. Best visual acuity was finger counting at 1 meter in all the
cases, which were subjected to the treatment. The cases were followed up for
2-4 years (2.5 years).
Results: In 10 cases visual acuity improved to
0.4 (20/50) in 1st week treatment. The best final visual acuity improvement was
20/30 in 8 and 20/40 in 2 cases.
Conclusions: Early Yag laser clot blast therapy is
useful for rapid improvement of the visual acuity and prevents the
complications secondary to central venous occlusion.
Most
of the cases of the occlusion of central retinal vein invariably turned out to
be unsuccessful with medical therapy given in the form of fibrinolytic agents,
anticoagulants, hemodilution” and steroid4. The cases that present with Ischemic
central retinal venous occlusion with visual acuity of 20/200 or less are
typically unfavorable’. In most instances, even the laser photocoagulation does
not yield a visual benefit compared with the natural course of the diseases.
Surgical decompression of branch retinal vein occlusion via arteriovenous
crossing sheathotomy has been tried successfully by some67’8 to treat these
cases but had led to complications associated with interventional vitrectomy
including accelerated nuclear sclerotic cataract formation and retinal
detachment. Others9 have tried to develop chorioretinal anastomosis at the site
of the venous block. However, others1° are trying to cannulise the blocked
central retinal vein. As no single treatment for central retinal vein is yet
successful, the authors tried a new modality of treatment in cases of central
venous retinal occlusion.
Methods and Materials
The
experimental procedure of Yag laser clot blast therapy was done in two blind
eyes due to old optic atrophy after taking a written consent. There were no
complications seen at time of laser application in the post laser follow up of
12 months. After this the present study was conducted at G.G.S.I.E Research
& Cure Centre from 1996 to 2001 after taking written consent of the patients.
There were 10 cases of central retinal venous block of ischemic type. The ages
of patients ranged from 24 to 70 years. In all the cases, best visual acuity
was recorded with Snellen projector chart [1]. Charting of fields and
ophthalmoscopic examination were done. The eyes were subjected to retinal
fluorescein angiography. The patient was made to sit on a slit lamp. After
insertion of mainster pan fundus contact lens, the Yag laser bursts of 1
.0milli Joules were started on the vein where it was entering as a branch or
main trunk on the optic disc, the settings of the laser were kept at 125micron
anterior. If the energy released was less, it was increased to 2 to 3milli
Joules. After giving 4 bursts at the disc, a total of 6-12 bursts were given
along the entire length of the blocked vein and venules till the 2nd A.V.
crossing (Figure1 ). The patients were sent back and were asked to report once
in a week till 4th week and then fortnightly till a follow up of 2-4 yrs
(2.5yrs) [2]. A complete examination of the eye including recording of best
visual acuity, field charting, intra-ocular pressure, slit lamp,
ophthalmoscopic examination and fluorescein angiography was done during the
follow up period.
Observation
a)
Visual Acuity: - It improved to 0.4 (20/50) in the first week of the treatment
in all the 10 cases. The improvement in visual acuity in subsequent weeks was
0.1 per week till 5th week. Final improvement in visual acuity to 0.8 (20/25)
was seen in 6 cases; to 0.7 (20/30) in 2 cases and 0.6 (20/33) in 1case and 0.5
(20/40) in one case. This visual acuity was maintained till a follow up of 2-4
years [3].
b)
Resolution of Fundus Lesions: - The typical fundus picture of the cases is
given which showed dilatation of the affected vein and venules with hemorrhages
and macular edema in all the cases (Figure 2). The pre-treatment fluorescein
angiography showed leakage of dye on the optic disc, in areas along the course
of vein (Figure 3) and after the treatment, it showed restoration of blood flow
with decrease in size of the venules, veins and absence of macular edema
(Figure 4). The lesions started resolving after the day of treatment and
completely resolved in 4-6 weeks (5 weeks).
c)
Complication: - No complications had occurred till date [4]. There was no
development of neo-vascularization in the retina, or in the angle of the
anterior chamber. No case had developed thrombotic glaucoma.
Discussion
The
idea of blasting of the dotted blood in the blocked central retinal vein struck
to me from the use of Yag laser in removing the pigment dust from the surfaces
of some implanted intra-ocular lenses. It was noticed that if we kept the
settings of slit lamp at 125micron anterior and gave a burst of 1-1.5milli
Joules, the dust got detached on a wider area of the implanted intra-ocular
lens without damaging the lens [5,6]. This analogy was applied in this study on
2 blind eyes that showed complete safety of this modality, as there were no
complications in the follow up, which further confirmed our idea to use it for
this purpose. In this study, 10 cases were studied by this technique. Review of
the literature showed that the initial improvement of the visual acuity with
other procedures took about 1-4 months5:7’5 as a result the improvement seen
after their procedures could not be definitely said to result from the
intervention only [7]. The visual acuity of the patients was finger counting at
1meter distance prior to the treatment. However, in the laser clot blast
therapy, the visual acuity improved to 0.4 (20/50) on 2nd day, which was clear
cut proof of the beneficial effect of the technique. It appeared that the Yag
laser energy had disintegrated the clotted blood in the blocked vein without
damaging the vein or the adjacent retinal tissue. Some authors preferred to
wait till complications of central retinal vein block started appearing. In our
opinion, it was not correct but an absurd approach as the damage was bound to
occur with uncertain outcome. Our study revealed that by opening of the flow in
the blocked central vein at the earliest, not only improved the visual results
but also shortened the recovery period with no subsequent complications. The
treatment in the form of laser clot therapy should be carried out irrespective
of the type of central retinal vein block. It should be carried out as an
urgent outdoor procedure irrespective of the age, sex or associated disease. In
the branch vein study groups, the final vision in laser treated eye improved to
20/40 to 20/50, compared with 20/70 in untreated eyes. Nevertheless, the
treatment effect was negligible when the initial vision was in the poorer range
of the 20/40 to 20/200 as inclusions criterion [8,9]. The treatment in the form
of photocoagulation1 is destructive and is aimed to treat cases who develop
neovascularization or non-resolving macular edema and not as an effort to
correct the main problem of venous occlusion. The other surgical procedures in form
of chorioretinal anastomosis, advential sheathotomy678 and cannulation°
although seem logical but are potentially hazardous with indefinite outcome.
The purpose of our investigation was an attempt to correct what we believed to
be the pathogenic mechanism in central retinal vein occlusion. We tried to lyse
the clotted blood or other intra-vascular factors, which had in our opinion,
lead on to the stasis of venous blood [10]. This therapy proved useful as it
improved the blood flow and abolished the occurrence of complications, which
usually occur in this condition
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